Integrative Analysis Unveils the Correlation of Aminoacyl-tRNA Biosynthesis Metabolites with the Methylation of the
Document Type
Article
Publication Date
9-2-2023
Publication Title
Genes (Basel)
Abstract
The impact of environmental factors on epigenetic changes is well established, and cellular function is determined not only by the genome but also by interacting partners such as metabolites. Given the significant impact of metabolism on disease progression, exploring the interaction between the metabolome and epigenome may offer new insights into Huntington's disease (HD) diagnosis and treatment. Using fourteen post-mortem HD cases and fourteen control subjects, we performed metabolomic profiling of human postmortem brain tissue (striatum and frontal lobe), and we performed DNA methylome profiling using the same frontal lobe tissue. Along with finding several perturbed metabolites and differentially methylated loci, Aminoacyl-tRNA biosynthesis (adj
Volume
14
Issue
9
First Page
1752
Recommended Citation
Vishweswaraiah S, Yilmaz A, Saiyed N, Khalid A, Koladiya PR, Pan X, et al [Graham SF] Integrative analysis unveils the correlation of aminoacyl-trna biosynthesis metabolites with the methylation of the sepsecs gene in huntington's disease brain tissue. Genes (Basel). 2023 Sep 2;14(9):1752. doi: 10.3390/genes14091752. PMID: 37761892.
DOI
10.3390/genes14091752
ISSN
2073-4425
PubMed ID
37761892