Bartonella Endocarditis Mimicking Crescentic Glomerulonephritis with PR3-ANCA Positivity.

Document Type

Article

Publication Date

8-2018

Abstract

Bartonella henselae is a fastidious organism that causes cat scratch disease, commonly associated with fever and lymphadenopathy but, in rare instances, also results in culture-negative infectious endocarditis. We describe a patient who presented with flank pain, splenic infarct, and acute kidney injury with an active urinary sediment, initially suspicious for vasculitis, which was subsequently diagnosed as B. henselae endocarditis. Bartonella endocarditis may present with a crescentic glomerulonephritis (GN) and elevated PR3-ANCA antibody titers, mimicking ANCA-associated GN, with 54 cases reported in the literature. Unique to our case in this series is a positive PR3-ANCA antibody despite a negative IIF-ANCA. Thus, the presentation of Bartonella can mimic ANCA-associated GN, and renal biopsy showing immune complex deposition is critical for diagnosis and appropriate treatment.

Volume

2018

First Page

9607582

Comments

American Society of Nephrology Kidney Week, New Orleans, LA, November 2, 2017.

Last Page

9607582

ISSN

2090-6641

PubMed ID

30210883

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