Paradigm shift in lifestyle modification for solitary kidney after donor nephrectomy.

Document Type

Article

Publication Date

1-1-2023

Publication Title

Current opinion in nephrology and hypertension

Abstract

PURPOSE OF REVIEW: Living donor kidney transplantation potentially leads to long-term complications including chronic kidney disease, end-stage kidney disease, elevated blood pressure, and pregnancy-associated hypertension. Given living donors generally do not have underlying medical conditions, lifestyle modifications, particularly dietary interventions may prevent those complications and improve their health outcomes.

RECENT FINDINGS: Glomerular hyperfiltration occurs as physiologic adaptation during an initial postdonor nephrectomy period. In the long-term, these adaptations may become pathologic consequences resulting from hyperfiltration-mediated kidney injury and ultimately secondary focal segmental glomerulosclerosis in the solitary kidney. Dietary interventions to slow a decline in kidney function include low protein intake of

SUMMARY: Although dietary interventions may provide benefits and kidney health for living kidney donors, further studies including clinical trials are required to incorporate them into clinical practice guidelines.

Volume

32

Issue

1

First Page

67

Last Page

75

DOI

10.1097/MNH.0000000000000853

ISSN

1473-6543

PubMed ID

36444664

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