"Five-Year Real-World Outcomes of Pulmonary Vein Isolation for Atrial F" by Yong Hao Yeo, Aravinthan Vignarajah et al.
 

Five-Year Real-World Outcomes of Pulmonary Vein Isolation for Atrial Fibrillation

Document Type

Conference Proceeding

Publication Date

4-1-2025

Publication Title

Journal of the American College of Cardiology

Abstract

Background: Pulmonary vein isolation (PVI) has shown growing evidence of efficacy and safety for rhythm control in atrial fibrillation (AF). However, large-scale, long-term studies evaluating this approach in real-world clinical settings remain limited. Methods: We used the TriNetX network to identify patients (≥18 years old) with AF between 2012-2018, dividing them into two groups based on whether they underwent PVI. Patients were followed for 5 years, with the primary outcome being a composite of all-cause death, ischemic stroke, and major bleeding (intracranial bleeding/ gastrointestinal bleeding), while secondary outcomes included all-cause hospitalization and heart failure exacerbation. Results: After propensity score matching, 39,480 patients were identified: 19,740 in each group. The primary composite outcomes occurred less frequently in patients with PVI (aOR, 0.48; 95% CI, 0.46 to 0.51; P< 0.01) than those without. They had lower odds of allcause mortality (aOR, 0.32; 95% CI, 0.30 to 0.35; P< 0.01), ischemic stroke (aOR, 0.70; 95% CI, 0.65 to 0.75; P< 0.01) and major bleeding (aOR, 0.53; 95% CI, 0.49 to 0.57; P< 0.01). They were also associated with lower odds of hospitalizations (aOR, 0.77; 95% CI, 0.74 to 0.81; P< 0.01) and heart failure exacerbations (aOR, 0.91; 95% CI, 0.87 to 0.95; P< 0.01). Conclusion: After a 5-year follow-up period, patients with AF who had PVI were associated with better clinical outcomes than those without.

Volume

85

Issue

12 Suppl

First Page

267

Comments

American College of Cardiology Meeting, March 29-31, 2025, Chicago, IL

Last Page

267

DOI

10.1016/S0735-1097(25)00752-1

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