Analysis of Trends, Healthcare Utilization, and Outcomes of Acute Pancreatitis in Patients with Liver Cirrhosis
Document Type
Conference Proceeding
Publication Date
5-2024
Publication Title
Gastroenterology
Abstract
INTRODUCTION: Acute pancreatitis (AP) and Liver cirrhosis are prevalent gastrointestinal entities that impose a significant healthcare burden globally and in the United States. A trend analysis was performed to identify hospitalization characteristics, clinical outcomes, and healthcare utilization for acute pancreatitis in patients with cirrhosis. METHODS: This is an observational retrospective study using the National Inpatient Sample database (2016–2020). All adult liver cirrhosis patients with acute pancreatitis were included using ICD-10-CM codes. A trend analysis was performed to identify hospitalization characteristics, clinical outcomes, and healthcare utilization trends. STATA® Version 17.0 Software (STATACORP, TEXAS, USA) was used for statistical analysis. A p-value of < 0.05 was considered statistically significant. RESULTS: From 2016 to 2020, there were 1,599 hospitalizations due to AP among a total of 182,044 individuals diagnosed with liver cirrhosis in the United States. We noted a rising trend of AP hospitalizations with liver cirrhosis from 305 in 2016 to 390 in 2020 (p=< 0.05). There was negligible change in age (62 years in 2016 to 63 years in 2020, p=< 0.05) for the study cohort. No significant racial disparity in trend was noted (p-trend=0.5). From a comorbidity perspective, there was a rising trend for patients with a Charlson Comorbidity Index (CCI) score >3 for AP hospitalizations with cirrhosis (p=< 0.05) (Table 1). After assessing individual comorbid conditions, we noted increasing trends of AP in patients with dyslipidemia, obesity, diabetes mellitus, chronic kidney disease, NASH, and malignancy (p= < 0.05). Interestingly no difference in AP was noted in chronic hepatitis B-related cirrhosis (p=0.8), compared to a decreasing trend in hepatitis C-related cirrhosis (p=< 0.05). Moreover, as expected, mean total healthcare charges increased from $69,653 in 2016 to $82,319 (p= < 0.05). However, no statistically significant difference was found in terms of length of stay (p=0.15) and in-hospital mortality (p=0.25). CONCLUSION: Our study highlights national trends of AP hospitalizations in patients with cirrhosis in the US. AP hospitalizations are on the rise, with an increasing comorbidity burden. Despite this upward trend, there is no observable shift in the overall inpatient mortality rates. The notable economic burden calls for a comprehensive approach to patient management, incorporating strategies that target the above-identified rising comorbid conditions to decrease the healthcare burden and overall patient care.
Volume
166
Issue
5 Suppl
First Page
S1586
Last Page
S1587
Recommended Citation
Vikash F, Hayat U, Abbasi AF, Parajuli S, Pulakurthi YS, Ozturk NB, et al. Analysis of trends, healthcare utilization, and outcomes of acute pancreatitis in patients with liver cirrhosis. Gastroenterology. 2024 May;166(5 Suppl):S1586-S1587. doi:10.1016/S0016-5085(24)04105-2
DOI
10.1016/S0016-5085(24)04105-2
Comments
DDW Digestive Disease Week, May 18-21, 2024, Washington, DC