Diagnostic Value of Diastolic Hyperemia-Free Ratio Compared to Invasive Fractional Flow Reserve

Document Type

Conference Proceeding

Publication Date

3-2023

Publication Title

Journal of the American College of Cardiology

Abstract

Background: There is limited data validating diastolic hyperemia-free ratio (DFR) against invasive fractional-flow reserve (FFR) in real-world clinical settings. We evaluated the diagnostic performance of DFR compared to FFR.Methods: We performed a prospective study of patients evaluated for stable ischemic heart disease or acute coronary syndrome who underwent both DFR and FFR for 40-90% stenoses between November 2019 and June 2021. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and diagnostic accuracy of DFR compared to FFR were calculated. Pearsonʼs correlation coefficient and receiver-operating characteristic (ROC) curves were used to estimate diagnostic accuracy of DFR.Results: We included 308 patients and 343 lesions. Positive FFR was found in 27% of lesions and positive DFR in 22% of lesions. When using FFR as the reference standard, the sensitivity, specificity, PPV, and NPV of DFR was 60%, 91%, 71%, and 87%, respectively. The overall diagnostic accuracy of DFR was 83%. Pearson correlation coefficient between DFR and FFR was 0.75 (p

Volume

81

Issue

8(Suppl. A)

First Page

1012

Comments

American College of Cardiology Annual Scientific Session & Expo with World Congress of Cardiology, March 4-6, 2023, New Orleans, LA

DOI

10.1016/S0735-1097(23)01456-0

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