High expression of MiR-98 is a good prognostic factor in acute myeloid leukemia patients treated with chemotherapy alone.
Document Type
Article
Publication Date
1-1-2019
Publication Title
Journal of Cancer
Abstract
It has been demonstrated that microRNA-98 (miR-98) is dysregulated in multiple types of solid tumors, but its expression and impact in acute myeloid leukemia (AML) is unclear. To explore the prognostic role of miR-98 in AML, 164 AML patients with the miR-98 expression data were extracted from The Cancer Genome Atlas (TCGA) database and enrolled in this study. First, patients were divided into chemotherapy-only (chemotherapy) group and allogeneic hematopoietic stem cell transplant (allo-HSCT) group. Each group was then divided in two groups by the median expression level of miR-98. In chemotherapy group, high miR-98 expression was associated with longer event-free survival (EFS,
Volume
10
Issue
1
First Page
178
Last Page
185
Recommended Citation
Hu N, Cheng Z, Pang Y, Zhao H, Chen L, Wang C, Qin T, Li Q, Han Y, Shi J, Fu L. High expression of MiR-98 is a good prognostic factor in acute myeloid leukemia patients treated with chemotherapy alone. J Cancer. 2019 Jan 1;10(1):178-185. doi: 10.7150/jca.26391. PMID: 30662538; PMCID: PMC6329859.
DOI
10.7150/jca.26391
ISSN
1837-9664
PubMed ID
30662538