Hydrochlorothiazide
Document Type
Article
Publication Date
1-2025
Publication Title
StatPearls [Internet]
Abstract
Hydrochlorothiazide is a medication approved by the U.S. Food and Drug Administration (FDA) to treat hypertension and peripheral edema. Hydrochlorothiazide is a thiazide-type diuretic that inhibits sodium resorption in the distal convoluted tubules of the kidney. Thiazides, a reliable class of antihypertensive diuretics for over 60 years,[1] have been shown to reduce major cardiovascular events.[2] Thiazides function by directly inhibiting the sodium chloride cotransporter, thereby preventing sodium reabsorption and inducing both natriuresis and diuresis effects. This activity comprehensively reviews the specific indications, mechanism of action, dosing, associated adverse events, contraindications, monitoring, and other clinically relevant information for healthcare professionals involved in managing hypertension and monitoring the effects of hydrochlorothiazide.
Recommended Citation
Herman LL, Weber P, Bashir K. Hydrochlorothiazide. 2023 Nov 12. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–. PMID: 28613517.
PubMed ID
28613517
Comments
Bookshelf ID: NBK430766