Impact of metabolically healthy obesity on post percutaneous coronary intervention outcomes in patients with acute myocardial infarction: A nationwide propensity matched analysis.
Document Type
Article
Publication Date
2-10-2025
Publication Title
Obesity pillars
Abstract
BACKGROUND: Obesity paradox in post-percutaneous coronary intervention (PCI) outcomes among acute myocardial infarction (AMI) patients is a known controversy. However, these studies included patients who had diabetes, hypertension, or hyperlipidemia. We studied relationship between metabolically healthy obesity (MHO-without diabetes, hypertension, or hyperlipidemia) and in-hospital post-PCI outcomes among AMI patients.
METHODS: We extracted data from National Inpatient Sample 2020 using International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) codes for admissions of AMI patients who underwent PCI. We then identified patients with diabetes, hypertension, and hyperlipidemia using Elixhauser comorbidity index and Clinical Classifications Software and excluded them. Then, using Elixhauser comorbidity index, we identified patients with and without obesity, defined as
RESULTS: Among 25605 metabolically healthy patients who had AMI and underwent PCI, 2825 had obesity, and 22780 didn't. After propensity score matching (PSM) for age and sex, both cohorts had 2795 patients each. There was no statistically significant difference in in-hospital all-cause mortality (adjusted odds ratio [OR] 1.14, 95 % confidence interval [CI] 0.63-2.10, p = 0.661), post-PCI stroke (aOR 1.17, 95 % CI 0.50-2.75, p = 0.714), acute kidney injury (aOR 1.20, 95 % CI 0.84-1.72, p = 0.322), post-PCI bleeding (aOR 1.04, 95 % CI 0.35 to 3.12, p = 0.940) and intra or post-PCI cardiac arrest (aOR 1.14, 95 % CI 0.30 to 4.42, p = 0.835) between both cohorts.
CONCLUSIONS: No statistically significant association was found between obesity and post-PCI outcomes in metabolically healthy patients with AMI. Larger studies are needed to explore the controversial "obesity paradox" in cardiovascular diseases.
Volume
14
First Page
100167
Recommended Citation
Desai R, Pingili A, Mahadevan A, Bejugam VR, Ahmed H, Borra V, et al Impact of metabolically healthy obesity on post percutaneous coronary intervention outcomes in patients with acute myocardial infarction: a nationwide propensity matched analysis. Obes Pillars. 2025 Feb 10;14:100167. doi: 10.1016/j.obpill.2025.100167. PMID: 40212728
DOI
10.1016/j.obpill.2025.100167
ISSN
2667-3681
PubMed ID
40212728
