Gender, Racial, and Geographical Disparities in Malignant Brain Tumor Mortality in the USA.

Authors

Jia Yi Tan
Jia Yean Thong
Yong Hao Yeo, Corewell Health East Resident
Kelly Mbenga
Sabera Saleh

Document Type

Article

Publication Date

2024

Publication Title

Oncology

Abstract

INTRODUCTION: Malignant brain tumors are malignancies which are known for their low survival rates. Despite advancements in treatments in the last decade, the disparities in malignant brain cancer mortality among the US population remain unclear.

METHODS: We analyzed death certificate data from the US CDC WONDER from 1999 to 2020 to determine the longitudinal trends of malignant brain tumor mortality. Malignant brain tumor (ICD-10 C71.0-71.9) was listed as the underlying cause of death. Age-adjusted mortality rates (AAMRs) per 100,000 individuals were calculated by standardizing the AAMR to the year 2000 US population.

RESULTS: From 1999 to 2020, there were 306,375 deaths due to malignant brain tumors. The AAMR decreased from 5.57 (95% CI, 5.47-5.67) per 100,000 individuals in 1999 to 5.40 (95% CI, 5.31-5.48) per 100,000 individuals in 2020, with an annual percent decrease of -0.05 (95% CI, -0.22, 0.12). Whites had the highest AAMR (6.05 [95% CI, 6.02-6.07] per 100,000 individuals), followed by Hispanics (3.70 [95% CI, 3.64-3.76]) per 100,000 individuals, blacks (3.09 [95% CI, 3.04-3.14] per 100,000 individuals), American Indians (2.82 [95% CI, 2.64-3.00] per 100,000 individuals), and Asians (2.44 [95% CI, 2.38-2.50] per 100,000 individuals). The highest AAMRs were reported in the Midwest region (5.58 [95% CI, 5.54-5.62] per 100,000 individuals) and the rural regions (5.66 [95% CI, 5.61-5.71] per 100,000 individuals).

CONCLUSIONS: Our study highlights the mortality disparity among different races, geographic regions, and urbanization levels. The findings underscore the importance of addressing the disparities in malignant brain tumors that existed among males, white individuals, and rural populations.

Volume

102

Issue

8

First Page

703

Last Page

709

Recommended Citation

Tan JY, Thong JY, Yeo YH, Mbenga K, Saleh S. Gender, Racial, and geographical disparities in malignant brain tumor mortality in the USA. Oncology. 2024;102(8):703-709. doi: 10.1159/000536486. PMID: 38281482.

DOI

10.1159/000536486

ISSN

1423-0232

PubMed ID

38281482