Safety and efficacy of cerebral embolic protection systems in transcatheter aortic valve replacement: a systematic review and meta-analysis.

Document Type

Article

Publication Date

12-27-2024

Publication Title

Expert review of cardiovascular therapy

Abstract

BACKGROUND: Stroke is a potential complication of Transcatheter Aortic Valve Replacement (TAVR). Recent trials evaluating Cerebral Embolic Protection Systems (CEPS) to reduce the incidence of stroke after TAVR have been conflicting.

METHODS: Multiple databases were searched for studies comparing TAVR with or without CEPS and that reported on the primary outcome of periprocedural stroke. Two authors individually screened the titles, the abstracts and the full texts using Covidence. Risk of bias was assessed using Cochrane's ROB-2 and ROBINS-I tools.

RESULTS: A total of 15 studies (3 randomized controlled trials, 7 national registries, and 5 cohort studies) met the eligibility criteria and were included in our review. CEPS was associated with lower rates of periprocedural stroke [OR 0.71 (95% CI 0.55, 0.93)

CONCLUSIONS: Our findings suggest that the use of CEPS in TAVR is associated with a lower risk of periprocedural stroke and mortality.

REGISTRATION: The PROSPERO identification number is CRD42022374055.

First Page

1

Last Page

8

DOI

10.1080/14779072.2024.2445256

ISSN

1744-8344

PubMed ID

39704660

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