Pleural Epithelioid Hemangioendothelioma: An Ultrarare Cause for Recurrent Pleural Effusion Managed With Trametinib and Pazopanib.

Authors

Ali Khreisat, Corewell Health Resident
Paul Bozyk, Corewell Health
Gloria Hong, Corewell Health Fellow
Casey P. Schukow, Corewell Health Resident

Document Type

Article

Publication Date

5-9-2024

Publication Title

Cureus

Abstract

Epithelioid hemangioendothelioma (EHE) is an extremely rare sarcoma of vascular origin. Primary pleural involvement is extremely under-reported and tends to have a more aggressive course. We report a case of pleural EHE in a Caucasian female in her 50s with a two-month history of dyspnea and chest pain. Investigations, including video-assisted thoracoscopy, revealed extensive pleural scarring and inflammation. Management with trametinib and pazopanib led to a stable disease course, reduction in the frequency of pleural effusion recurrence, and improvement in cancer-related pain.

Volume

16

Issue

5

First Page

e60002

Recommended Citation

Khreisat A, Bozyk P, Hong G, Schukow CP. pleural epithelioid hemangioendothelioma: an ultrarare cause for recurrent pleural effusion managed with trametinib and pazopanib. Cureus. 2024 May 9;16(5):e60002. doi: 10.7759/cureus.60002. PMID: 38736758

DOI

10.7759/cureus.60002

ISSN

2168-8184

PubMed ID

38736758