Antisynthetase Syndrome With Paraneoplastic Antibodies.
Antisynthetase syndrome (ASyS) is an uncommon systemic autoimmune disorder characterized by the presence of autoantibodies targeting aminoacyl-transfer RNA (tRNA) synthetase. The syndrome displays a diverse range of clinical manifestations affecting multiple organs, thereby posing a diagnostic challenge. In this report, we present an unusual case of a patient diagnosed with ASyS, displaying positive anti-PL-12 antibodies along with paraneoplastic antibodies. To the best of our knowledge, this is the first documented case in the existing literature describing ASyS with the presence of anti-PL-12 antibodies and concomitant paraneoplastic antibodies in the context of ductal carcinoma in situ.
Pokharel A, Karageorgiou I, Acharya I, Billups T, Bateman J. Antisynthetase syndrome with paraneoplastic antibodies. Cureus. 2023 Jun 13;15(6):e40354. doi: 10.7759/cureus.40354. PMID: 37366475.