Antisynthetase Syndrome With Paraneoplastic Antibodies.

Authors

Ashbina Pokharel, Beaumont Health
Ioannis Karageorgiou, Beaumont Health
Indira Acharya
Tucker Billups, Beaumont Health
Judith Bateman, Beaumont Health

Document Type

Article

Publication Date

6-13-2023

Publication Title

Cureus

Abstract

Antisynthetase syndrome (ASyS) is an uncommon systemic autoimmune disorder characterized by the presence of autoantibodies targeting aminoacyl-transfer RNA (tRNA) synthetase. The syndrome displays a diverse range of clinical manifestations affecting multiple organs, thereby posing a diagnostic challenge. In this report, we present an unusual case of a patient diagnosed with ASyS, displaying positive anti-PL-12 antibodies along with paraneoplastic antibodies. To the best of our knowledge, this is the first documented case in the existing literature describing ASyS with the presence of anti-PL-12 antibodies and concomitant paraneoplastic antibodies in the context of ductal carcinoma in situ.

Volume

15

Issue

6

First Page

e40354

Recommended Citation

Pokharel A, Karageorgiou I, Acharya I, Billups T, Bateman J. Antisynthetase syndrome with paraneoplastic antibodies. Cureus. 2023 Jun 13;15(6):e40354. doi: 10.7759/cureus.40354. PMID: 37366475.

DOI

10.7759/cureus.40354

ISSN

2168-8184

PubMed ID

37366475