Cholestatic Hepatitis in Graves' Disease: A Diagnostic Challenge.

Document Type

Article

Publication Date

1-2021

Publication Title

ACG Case Rep J

Abstract

Cholestatic hepatitis is a rare presentation of thyrotoxicosis potentially confused as an adverse effect of antithyroid therapy. We report a 37-year-old man with cholestatic hepatitis as an initial presentation of Graves' disease. Diagnostic evaluation demonstrated (i) elevated transaminases and alkaline phosphatase (R-factor value: 2.6), and marked cholestasis (total bilirubin: 17.3 mg/dL, direct bilirubin: 9.4 mg/dL); (ii) negative hepatitis, viral, and autoimmune serologies; (iii) normal magnetic resonance cholangiopancreatography; (iv) liver biopsy with marked cholestasis and no fibrosis; (v) thyroid-stimulating hormone

Volume

8

Issue

1

First Page

e00526

DOI

10.14309/crj.0000000000000526

ISSN

2326-3253

PubMed ID

33490298

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