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  Review of Salvage Therapy for MRSA Bacteremia at Beaumont Health System

  Hazem Alakhras, Matthew D. Sims, and Tracey A.H. Taylor

  Publication Date: 5-2023

  Treating methicillin-resistant Staphylococcus aureus (MRSA) effectively is imperative to reduce mortality rates, as it contributes to a large amount of healthcare-associated bacteremia in the U.S. However, due to the insufficient and sometimes contradicting studies to guide salvage therapy, there is a lack of clear consensus on treatment of MRSA bacteremia after vancomycin failure. The goal of this study is to showcase the salvage therapies of choice for patients with MRSA bacteremia at Beaumont Health System.

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  Combining DRIP Score and Rapid Diagnostics For Improved Antibiotic Stewardship

  Richard Ramirez and Matthew Sims

  Publication Date: 5-2023

  Treatment analysis patterns for broad-spectrum antibiotic use in pneumonia revealed that 60% of patients were overtreated, highlighting the need for effective antibiotic stewardship practices. Systems such as the Drug Resistance in Pneumonia (DRIP) score select patients more likely to require broad spectrum antibiotics but still leads to overtreatment as it does not target specific pathogens. Rapid diagnostics such as the Unyvero Lower Respiratory Tract Panel (LRTP) combined with the DRIP score can identify specific pathogens to further narrow antibiotic use.

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  Designing a Surgical Scorecard to Inform and Evaluate Appropriate Perioperative Antibiotic Prophylaxis

  Rehan Tariq and Paul Chittick

  Publication Date: 5-2023

  Perioperative antibiotic prophylaxis (PAP) implementation is a widespread strategy used to ensure the minimization of surgical site infections (SSIs) during various surgical procedures including hip and knee replacements and organ transplants. Despite the widespread implementation of PAP, there exists a gap in understanding what is considered appropriate PAP. This may be due in part to the absence of a feedback mechanism that educates physicians on which antibiotics are truly appropriate for preventing the SSIs arising from certain surgical procedures. The goal of this project is to design an informative surgical prophylaxis scorecard that physicians can use to determine which antibiotic is appropriate for PAP. We are interested in the impact our quality improvement tool will have on appropriate perioperative prophylaxis services at Beaumont Royal Oak.

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  Quality Improvement Study on Human Papilloma Virus (HPV) Vaccination uptake in HIV patients

  Hassan Akram, Paul Johnson, and Trini A Mathew

  Publication Date: 5-2-2022

  INTRODUCTION HPV is strongly associated with cervical cancer and cancers of vagina, vulva, penis, anus, rectum. In 2019, WHO identified vaccine hesitancy as top 10 global threats and planned to increase the HPV vaccine coverage. In June 2019 Advisory Committee on Immunization Practices (ACIP) in the US recommended shared clinical decision-making regarding HPV vaccinations in adults aged 26 through 45 years. The goal of this project is to evaluate the uptake of HPV vaccination and challenges in the HIV patients at Beaumont Hospital.

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  Resistance in Gram-Negative Bacteria in the Pediatric Patient Population by Age and Sex

  Benjamin Malamet and Matthew Sims

  Publication Date: 5-2-2022

  INTRODUCTION
  Previous research within the Beaumont Infectious Diseases Research Program found an increase in antibiotic resistance in adult males versus females. Furthermore, there is a peak in resistance in 18-29-year-old males, not seen in females. The origin of this early peak of antibiotic resistance in adults is unclear. This study examines these trends in the pediatric patient population.

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  Relatedness Of Urinary Escherichia Coli Strains And Connection Between Strain Type And Clinical Presentation

  Anet Szatkowski, Venkathesh Bai, and Matthew D. Sims

  Publication Date: 5-2-2022

  INTRODUCTION
  Urine is often not a sterile body fluid. When bacteria in the urine cause symptoms it is by definition a urinary tract infection (UTI). The specific symptoms will point toward a bladder infection (cystitis) or a kidney infection (pyelonephritis). Presence of bacteria in the urine without symptoms defines asymptomatic bacteriuria (AB). Despite requiring symptoms to diagnose a UTI, often AB is misdiagnosed as a UTI and treated with antibiotics when none are needed. Escherichia coli is the most common cause of UTIs accounting for 80-90% of community-acquired UTIs and 30-50% of nosocomial UTIs. The goals of this study are to determine whether specific strains of E. coli are associated with cystitis, pyelonephritis, or asymptomatic bacteriuria; whether specific strains are related to more serious infections; and whether specific strains can be geomapped to specific areas within Southeast Michigan using postal codes.