Epidemiology, Clinical Features, and Antimicrobial Resistance of Invasive
Document Type
Article
Publication Date
1-27-2023
Publication Title
Open forum infectious diseases
Abstract
BACKGROUND: Invasive
METHODS: We applied clinical criteria of systemic inflammatory response syndrome (SIRS), sepsis, or septic shock to patients hospitalized with culture-confirmed
RESULTS: Most patients with IED (N = 902) were adults aged ≥60 years (76.5%); 51.9%, 25.1%, and 23.0% of cases were community-acquired (CA), hospital-acquired (HA), and healthcare-associated (HCA), respectively. The urinary tract was the most common source of infection (52.3%). Systemic inflammatory response syndrome, sepsis, and septic shock were identified in 77.4%, 65.3%, and 14.1% of patients, respectively. Patients >60 years were more likely to exhibit organ dysfunction than those ≤60 years; this trend was not observed for SIRS. The case-fatality rate (CFR) was 20.0% (60-75 years, 21.5%; ≥75 years, 22.2%), with an increase across IED acquisition settings (HA, 28.3%; HCA, 21.7%; CA, 15.2%). Noticeably, 77.8% of patients initiated antibiotic use on the day of culture sample collection. A total of 65.6% and 40.8% of
CONCLUSIONS: This study contributes valuable, real-world data about IED severity. An accepted case definition could promote timely and accurate diagnosis of IED and inform the development of novel preventative strategies.
Volume
10
Issue
2
First Page
ofad026
Recommended Citation
Doua J, Geurtsen J, Rodriguez-Baño J, Cornely OA, Go O, Gomila-Grange A, et al [Sims M] Epidemiology, clinical features, and antimicrobial resistance of invasive escherichia coli disease in patients admitted in tertiary care hospitals. Open Forum Infect Dis. 2023 Jan 27;10(2):ofad026. doi: 10.1093/ofid/ofad026. PMID: 36817744
DOI
10.1093/ofid/ofad026
ISSN
2328-8957
PubMed ID
36817744