Fungal Infections in Hematopoietic Stem-Cell Transplant Patients: A Review of Epidemiology, Diagnosis, and Management.

Document Type

Article

Publication Date

8-19-2021

Publication Title

Therapeutic Advances in Infectious Disease

Abstract

The advent of bone marrow transplant has opened doors to a different approach and offered a new treatment modality for various hematopoietic stem-cell-related disorders. Since the first bone marrow transplant in 1957, there has been significant progress in managing patients who undergo bone marrow transplants. Plasma-cell disorders, lymphoproliferative disorders, and myelodysplastic syndrome are the most common indications for hematopoietic stem-cell transplant. Despite the advances, invasive fungal infections remain a significant cause of morbidity and mortality in this high-risk population. The overall incidence of invasive fungal infection in patients with hematopoietic stem-cell transplant is around 4%, but the mortality in patients with allogeneic stem-cell transplant is as high as 13% in one study. Type of stem-cell transplant, conditioning regimen, and development of graft-

Volume

8

First Page

20499361211039050

Last Page

20499361211039050

DOI

10.1177/20499361211039050

ISSN

2049-9361

PubMed ID

34434551

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