Current Perspectives on Diagnostic Assays and Anti-PF4 Antibodies for the Diagnosis of Heparin-Induced Thrombocytopenia.

Authors

Kamal K Sahu
Vishal Jindal, Beaumont Health Fellow
Joseph Anderson, Beaumont Health Fellow
Ahmad D Siddiqui
Ishmael A Jaiyesimi, Beaumont Health

Document Type

Article

Publication Date

8-17-2020

Publication Title

Journal of Blood Medicine

Abstract

Heparin-induced thrombocytopenia (HIT) is a recognized clinical entity in patients receiving unfractionated heparin and low-molecular weight heparin. Currently, diagnosing HIT includes the combination of a physician's clinical suspicion based on a clinical scoring system and a series of laboratory tests. In the present article, we discuss challenges in suspecting and diagnosing HIT in consideration of the turnaround time of available tests and recent advances in techniques and methodologies of newer immunoassays and functional assays.

Volume

11

First Page

267

Last Page

277

Recommended Citation

Sahu KK, Jindal V, Anderson J, Siddiqui AD, Jaiyesimi IA. Current Perspectives on Diagnostic Assays and Anti-PF4 Antibodies for the Diagnosis of Heparin-Induced Thrombocytopenia. J Blood Med. 2020 Aug 17;11:267-277. doi: 10.2147/JBM.S232648. PMID: 32884385; PMCID: PMC7443028.

DOI

10.2147/JBM.S232648

ISSN

1179-2736

PubMed ID

32884385