Up-regulation of DDIT4 predicts poor prognosis in acute myeloid leukaemia.

Document Type

Article

Publication Date

1-1-2020

Publication Title

Journal of Cellular and Molecular Medicine

Abstract

The mammalian target of rapamycin (mTOR) inhibitor, DNA damage inducible transcript 4 (DDIT4), has inducible expression in response to various cellular stresses. In multiple malignancies, studies have shown that DDIT4 participates in tumorigenesis and impacts patient survival. We aimed to study the prognostic value of DDIT4 in acute myeloid leukaemia (AML), which is currently unclear. Firstly, The Cancer Genome Atlas was screened for AML patients with complete clinical characteristics and DDIT4 expression data. A total of 155 patients were included and stratified according to the treatment modality and the median DDIT4 expression levels. High DDIT4 expressers had shorter overall survival (OS) and event-free survival (EFS) than the low expressers among the chemotherapy-only group (all P < .001); EFS and OS were similar in the high and low DDIT4 expressers of the allogeneic haematopoietic stem cell transplantation (allo-HSCT) group. Furthermore, in the DDIT4

Volume

24

Issue

1

First Page

1067

Last Page

1075

DOI

10.1111/jcmm.14831

ISSN

1582-4934

PubMed ID

31755224

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