Cardiotoxicity of Biological Therapies in Cancer Patients: An In-depth Review.
Document Type
Article
Publication Date
2023
Publication Title
Current cardiology reviews
Abstract
Cardiotoxicity from chemotherapy regimens has been long reported. However, the understanding of cardiac side effects of biological therapies is rapidly evolving. With cancer patients achieving higher life expectancy due to the use of personalized medicine and novel targeted anticancer agents, the occurrence of cardiotoxicity is becoming more significant. Novel biological therapies include anti-HER2 antibodies, tyrosine kinase inhibitors, bruton kinase inhibitors, antivascular endothelial growth factors, proteasome inhibitors, immunomodulator drugs, and immune checkpoint inhibitors. Potential cardiovascular toxicities linked to these anticancer agents include hypertension, arrhythmias, QT prolongation, myocardial ischemia and infarction, left ventricular dysfunction, congestive heart failure, and thromboembolism. Cardiac biomarkers, electrocardiography, echocardiography and magnetic resonance imaging are common diagnostic modalities used for early detection of these complications and timely intervention. This review discusses the various types of cardiotoxicities caused by novel anticancer biologic agents, their molecular and pathophysiological mechanisms, risk factors, and diagnostic and management strategies that can be used to prevent, minimize, and treat them.
Volume
19
Issue
3
First Page
310522205428
Recommended Citation
Madanat L, Gupta R, Weber P, Kumar N, Chandra R, Ahaneku H, et al[Anderson J, Bilolikar A, Jaiyesimi I] Cardiotoxicity of biological therapies in cancer patients: an in-depth review. Curr Cardiol Rev. 2023;19(3):e310522205428. doi: 10.2174/1573403X18666220531094800. PMID: 35642110
DOI
10.2174/1573403X18666220531094800
ISSN
1875-6557
PubMed ID
35642110