Impact of Co-Existent Inflammatory Bowel Disease on Outcomes in Acute Pancreatitis an Analysis of the National Inpatient Sample (NIS) Database
Document Type
Conference Proceeding
Publication Date
5-2024
Publication Title
Gastroenterology
Abstract
Background: Pancreatitis is an infrequent extra-intestinal manifestation of inflammatory bowel disease (IBD). We analyzed data from the National (Nationwide) Inpatient Sample (NIS) with the aim of evaluating the outcomes of acute pancreatitis (AP) in patients with co-existent IBD. Objectives: To evaluate whether IBD has any effect on major outcomes on patients with AP, including in-hospital mortality. Design and setting: Retrospective cohort study by using the 2020 National Inpatient Sample. Patients: Patients were included if they were adults with a principal diagnosis of AP. Main outcome measurements: In-hospital mortality, length of stay, hospital total charges, hypovolemic shock, severe sepsis with and without shock and acute kidney failure (AKI) Results: Among the 32 million discharges in 2020 NIS database, there were 258,965 admissions with primary diagnosis of AP. A total of 1930 of 258,965 (0.75%) and 1170 of 258,965 (0.45%) hospitalizations for AP had coexisting Crohn’s disease (CD) and Ulcerative colitis (UC) respectively. Patient characteristics for those admitted with AP with coexisting IBD were most likely whites, mean age of 48- year-old, had a lower Charlson Comorbidity Index score, a lower median annual income and had primarily private insurance. CD patients with AP presentation were more likely to be females (statistically significant) while UC patients, were mostly males [was not statistically significant (p=0.72)]. The overall in-hospital mortality for AP was 0.62%. Patients with UC hospitalized for AP had increased odds of in-hospital mortality (adjusted odds ratio [aOR]: 3.62, 95% CI 1.310-9.978, p=0.013) while for patients with CD, there were no in-hospital mortality. CD patients had increased odds of developing comorbid AKI (aOR: 1.37, 95% CI 1.005-1.880, p=0.047) when they present with AP but not those with UC. There was no statistical difference, however, in length of stay, hospital total charges, hypovolemic shock and septic shock in hospitalized patients with AP whether they had IBD or not. Limitations: Retrospective data, administrative database Conclusions: Patients hospitalized with AP had an increased odds of in-hospital mortality and comorbid AKI when they have coexistent UC and CD respectively. There was no statistical difference in length of stay, hospital total charges, hypovolemic shock and sepsis with and without shock for IBD patients presenting with AP.
Volume
166
Issue
5 Suppl
First Page
S451
Last Page
S452
Recommended Citation
Alexander D, Jamil LH. Impact of co-existent inflammatory bowel disease on outcomes in acute pancreatitis: an analysis of the National Inpatient Sample (NIS) database. Gastroenterology. 2024 May;166(5 Suppl):S451-S452. doi: 10.1016/S0016-5085(24)01513-0
DOI
10.1016/S0016-5085(24)01513-0
Comments
DDW Digestive Disease Week, May 18-21, 2024, Washington, DC