Outcomes of total pancreatectomy with islet autotransplantation: A systematic review and meta-analysis.
World Journal of Transplantation
BACKGROUND: Despite the increased use of total pancreatectomy with islet autotransplantation (TPIAT), systematic evidence of its outcomes remains limited.
AIM: To evaluate the outcomes of TPIAT.
METHODS: We searched PubMed, EMBASE, and Cochrane databases from inception through March 2019 for studies on TPIAT outcomes. Data were extracted and analyzed using comprehensive meta-analysis software. The random-effects model was used for all variables. Heterogeneity was assessed using the I
RESULTS: Twenty-one studies published between 1980 and 2017 examining 1011 patients were included. Eighteen studies were of adults, while three studied pediatric populations. Narcotic independence was achieved in 53.5% [95% Confidence Interval (CI): 45-62,
CONCLUSION: These results indicate acceptable success for TPIAT. Future studies should evaluate the discussed measures before and after surgery for comparison.
Khazaaleh S, Babar S, Alomari M, Imam Z, Chadalavada P, Gonzalez AJ, et al. Outcomes of total pancreatectomy with islet autotransplantation: a systematic review and meta-analysis. World J Transplant. 2023 Jan 18;13(1):10-24. doi: 10.5500/wjt.v13.i1.10. PMID: 36687559.