Outcomes of total pancreatectomy with islet autotransplantation: A systematic review and meta-analysis.

Document Type

Article

Publication Date

1-18-2023

Publication Title

World Journal of Transplantation

Abstract

BACKGROUND: Despite the increased use of total pancreatectomy with islet autotransplantation (TPIAT), systematic evidence of its outcomes remains limited.

AIM: To evaluate the outcomes of TPIAT.

METHODS: We searched PubMed, EMBASE, and Cochrane databases from inception through March 2019 for studies on TPIAT outcomes. Data were extracted and analyzed using comprehensive meta-analysis software. The random-effects model was used for all variables. Heterogeneity was assessed using the I

RESULTS: Twenty-one studies published between 1980 and 2017 examining 1011 patients were included. Eighteen studies were of adults, while three studied pediatric populations. Narcotic independence was achieved in 53.5% [95% Confidence Interval (CI): 45-62,

CONCLUSION: These results indicate acceptable success for TPIAT. Future studies should evaluate the discussed measures before and after surgery for comparison.

Volume

13

Issue

1

First Page

10

Last Page

24

DOI

10.5500/wjt.v13.i1.10

ISSN

2220-3230

PubMed ID

36687559

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