Outcomes of total pancreatectomy with islet autotransplantation: A systematic review and meta-analysis.

Authors

Shrouq Khazaaleh
Sumbal Babar
Mohammad Alomari
Zaid Imam, Beaumont Health Fellow
Pravallika Chadalavada
Adalberto Jose Gonzalez
Bara El Kurdi

Document Type

Article

Publication Date

1-18-2023

Publication Title

World Journal of Transplantation

Abstract

BACKGROUND: Despite the increased use of total pancreatectomy with islet autotransplantation (TPIAT), systematic evidence of its outcomes remains limited.

AIM: To evaluate the outcomes of TPIAT.

METHODS: We searched PubMed, EMBASE, and Cochrane databases from inception through March 2019 for studies on TPIAT outcomes. Data were extracted and analyzed using comprehensive meta-analysis software. The random-effects model was used for all variables. Heterogeneity was assessed using the I

RESULTS: Twenty-one studies published between 1980 and 2017 examining 1011 patients were included. Eighteen studies were of adults, while three studied pediatric populations. Narcotic independence was achieved in 53.5% [95% Confidence Interval (CI): 45-62,

CONCLUSION: These results indicate acceptable success for TPIAT. Future studies should evaluate the discussed measures before and after surgery for comparison.

Volume

13

Issue

1

First Page

10

Last Page

24

Recommended Citation

Khazaaleh S, Babar S, Alomari M, Imam Z, Chadalavada P, Gonzalez AJ, et al. Outcomes of total pancreatectomy with islet autotransplantation: a systematic review and meta-analysis. World J Transplant. 2023 Jan 18;13(1):10-24. doi: 10.5500/wjt.v13.i1.10. PMID: 36687559.

DOI

10.5500/wjt.v13.i1.10

ISSN

2220-3230

PubMed ID

36687559