Leukemia Cutis With Concomitant Seborrheic Keratosis as the Presenting Symptom of Chronic Lymphocytic Leukemia: A Case Report.
Document Type
Article
Publication Date
4-17-2025
Publication Title
Cureus
Abstract
Leukemia cutis is a term used to describe a dermatologic manifestation of hematologic malignancies. It represents a wide range of identifiable cutaneous lesions that result from the infiltration of neoplastic leukocytes in patients with leukemia or lymphoma. We report a case involving an initial solitary lesion without systemic symptoms, but a biopsy revealed a seborrheic keratosis in the epidermis with lymphoid infiltration in the dermis. Flow cytometry studies confirmed a B-cell chronic lymphocytic leukemia, and an additional investigation with fluorescence in situ hybridization demonstrated a chromosomal deletion in the long arm of chromosome 13 at position 14, indicating a favorable prognosis. The patient was referred to a hematologist, who determined that no pharmacologic treatment was necessary at that time. The patient continues to follow up for monitoring of his disease.
Volume
17
Issue
4
First Page
e82433
Recommended Citation
Drallmeier M, Ranspach L, Elias G. leukemia cutis with concomitant seborrheic keratosis as the presenting symptom of chronic lymphocytic leukemia: a case report. Cureus. 2025 Apr 17;17(4):e82433. doi: 10.7759/cureus.82433. PMID: 40385890.
DOI
10.7759/cureus.82433
ISSN
2168-8184
PubMed ID
40385890
