Allometric body shape indices, type 2 diabetes and kidney function: A two-sample Mendelian randomization study.

Document Type

Article

Publication Date

7-1-2023

Publication Title

Diabetes, Obesity & Metabolism

Abstract

AIM: To examine the association between body mass index (BMI)-independent allometric body shape indices and kidney function.

MATERIALS AND METHODS: We performed a two-sample Mendelian randomization (MR) analysis, using summary statistics from UK Biobank, CKDGen and DIAGRAM. BMI-independent allometric body shape indices were: A Body Shape Index (ABSI), Waist-Hip Index (WHI) and Hip Index (HI). Kidney function outcomes were: urinary albumin-to-creatinine ratio (UACR), estimated glomerular filtration rate and blood urea nitrogen. Furthermore, we investigated type 2 diabetes (T2D) as a potential mediator on the pathway to albuminuria. The main analysis was inverse variance-weighted random-effects MR in participants of European ancestry. We also performed several sensitivity MR analyses.

RESULTS: A 1-standard deviation (SD) increase in genetically predicted ABSI and WHI levels was associated with higher UACR (β = 0.039 [95% confidence interval: 0.016, 0.063] log [UACR], P = 0.001 for ABSI, and β = 0.028 [0.012, 0.044] log [UACR], P = 6 x 10

CONCLUSIONS: Genetically high HI was associated with decreased risk of albuminuria, mediated through decreased T2D risk in both sexes. Opposite associations applied to genetically high ABSI and WHI in women only.

Volume

25

Issue

7

First Page

1803

Last Page

1812

DOI

10.1111/dom.15037

ISSN

1463-1326

PubMed ID

36855799

Link to Full Text

Share

COinS