Early intranasal medication administration in out-of-hospital cardiac arrest: Two randomized simulation trials.

Document Type

Article

Publication Date

2-1-2024

Publication Title

J Am Coll Emerg Physicians Open

Abstract

OBJECTIVE: Intranasal medications have been proposed as adjuncts to out-of-hospital cardiac arrest (OHCA) care. We sought to quantify the effects of intranasal medication administration (INMA) in OHCA workflows.

METHODS: We conducted separate randomized OHCA simulation trials with lay rescuers (LRs) and first responders (FRs). Participants were randomized to groups performing hands-only cardiopulmonary resuscitation (CPR)/automated external defibrillator with or without INMA during the second analysis phase. Time to compression following the second shock (CPR2) was the primary outcome and compression quality (chest compression rate (CCR) and fraction (CCF)) was the secondary outcome. We fit linear regression models adjusted for CPR training in the LR group and service years in the FR group.

RESULTS: Among LRs, INMA was associated with a significant increase in CPR2 (mean diff. 44.1 s, 95% CI: 14.9, 73.3), which persisted after adjustment (

CONCLUSIONS: INMA in LR resuscitation was associated with diminished resuscitation performance. INMA by FR did not impede key times or quality.

Volume

5

Issue

1

First Page

13100

Last Page

13100

DOI

10.1002/emp2.13100

ISSN

2688-1152

PubMed ID

38260004

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