Anti-Kelch Like 11 Protein Encephalitis in a Patient with a Regressed Testicular Germ Cell Tumor

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Authors

Ryan Bean, Corewell Health West Resident
Jordan Gates, Corewell Health West Resident
Nicholas Lannen, Corewell Health West

Description

Kelch-like protein 11 (KLHL11) antibody encephalitis is an intracellular antibody-associated paraneoplastic syndrome, associated with testicular germ cell tumors and teratomas. Through T-cell mediated destruction of KLHL11-expressing neurons, KLHL11 antibody encephalitis has varied clinical manifestations, and is often characterized by rhombencephalitis, cochleovestibulopathy, and limbic encephalitis that is poorly responsive to immunotherapy.

Publication Date

5-9-2025

Disciplines

Neurology

Recommended Citation

Bean R, Gates J, Lannen N. Anti-Kelch like 11 protein encephalitis in a patient with a regressed testicular germ cell tumor. Presented at: Research Day Corewell Health West; 2025 May 9; Grand Rapids, MI.

Comments

2025 Research Day Corewell Health West, Grand Rapids, MI, May 9, 2025. Abstract 1671