Outcomes of Brachytherapy Comparing Coronary Bypass Grafts vs Native Vessels
Document Type
Conference Proceeding
Publication Date
5-2025
Publication Title
Journal of the Society for Cardiovascular Angiography and Interventions
Abstract
Background: Coronary artery in-stent restenosis (ISR) is a common challenge after treating coronary artery disease with a bare metal or drug-eluting stent (DES). Intravascular brachytherapy (IVBT) using radioactive isotopes is an effective treatment option for patients with recurrent ISR to avoid further luminal narrowing. There is limited data in the modern era comparing long term outcomes of IVBT used in native coronary arteries vs coronary artery bypass grafts in those experiencing recurrent ISR. Methods: This is a single institution retrospective study of 282 patients that underwent coronary brachytherapy following ISR of a previous DES between September 2014 and May 2023. Kaplan Meier analysis was used to assess the clinical endpoints of freedom from target vessel reintervention (TVR), death, and major adverse cardiac events (MACE), defined as myocardial infarction, TVR, or death. Results: A total of 248 patients were included in the study which compared the outcomes of 49 bypass grafts and 199 native arteries that underwent IVBT for recurrent ISR. At both 1, 3 and 5 year follow up, event-free survival was similar in patients with native arteries vs bypass grafts (p = 0.45, 0.3 and 0.12 respectfully). Additional Kaplan Meir analysis of TVR and death did not show statistical significance at 1, 3 and 5 year follow up. Conclusions: Our data suggest that the long-term clinical outcome of patients with native coronary arteries is similar between those with bypass graft vessels when treated with IVBT for recurrent ISR.
Volume
4
Issue
5 Suppl
First Page
50
Last Page
50
Recommended Citation
Hanna M, Petrykowski N, Kondoleon NP, Chhabra K, Lee K, Hanson I. Outcomes of brachytherapy comparing coronary bypass grafts vs native vessels. J Soc Cardiovasc Angiogr Interv. 2025 May;4(5 Suppl):50. doi: 10.1016/j.jscai.2025.103227
DOI
10.1016/j.jscai.2025.103227
Comments
Society for Cardiovascular Angiography & Interventions SCAI 48th Annual Scientific Sessions, May 1-3, 2025, Washington, DC