Temporal and Age-Related Trends in Risk Factors for Development of Atrial Fibrillation in Peripartum Patients

Authors

Edward Yu
Barqadle Ali
Nishaki K. Mehta, Corewell Health
Saima Karim

Document Type

Conference Proceeding

Publication Date

10-28-2024

Publication Title

European Heart Journal

Abstract

Background: Incidence of atrial fibrillation (AF) in pregnancy has steadily increased over the past two decades and may be related to changes in rates of AF risk factors.

Objective: To characterize trends in the prevalence of AF risk factors among patients with peripartum AF.

Methods: TrinetX, a large national healthcare database, was used to identify patients with peripartum AF from 2017-2022. Inclusion criteria were female patients aged >18 years old who received a diagnosis of AF within one month prior to and one year after a diagnosis of pregnancy. Annual prevalence of pre-existing AF risk factors, including diabetes, chronic kidney disease (CKD), obesity, and hypertension, were obtained, normalized to the annual number of peripartum AF cases, and followed. In a secondanalysis, student’s t-test and standardized mean difference were used to compare the rates of AF risk factors between patients with peripartum AF and pregnant patients with no history of AF within the same time frame. Comparisons were performed across age ranges. Results: From 2017-2022,there were 6,465patients with peripartum AF and 2,852,348 pregnant patients with no AF. There was an increase in the proportion of peripartum AF patients with pre-existing obesity (16.7% to 18.5%) and hypertension (28.9% to 33.7%). In comparing pregnant patients with no AF history with peripartum AF patients, the standardized mean difference for rates of all risk factors increased with age group. The peripartum AF group had significantly higher rates of all risk factors across all age groups (p < 0.0001 for all groups). Conclusion:Ratesofpre-existingobesity and hypertensionincreasedamongpatients withperipartum AF,which couldbe afactorin increasing rates of peripartum AF. Differences in rates of AF risk factors between peripartum AF patients and pregnant patients with no AF were more pronounced at older age groups.

Volume

45

Issue

1 Supplement

First Page

S1

Comments

European Society of Cardiology 2024 Congress, August 30-September 2, 2024, London, England.

Recommended Citation

Yu E, Ali B, Mehta NK, Karim S. Temporal and age-related trends in risk factors for development of atrial fibrillation in peripartum patients. Eur Heart J. 2024 Oct 28;45(Supplement_1):S1.doi: 10.1093/eurheartj/ehae666.473.