"Effect of Sex and Flow Status on Outcomes After Surgical or Transcathe" by Rasmus Carter-Storch, Rebecca T. Hahn et al.
 

Effect of Sex and Flow Status on Outcomes After Surgical or Transcatheter Aortic Valve Replacement.

Document Type

Article

Publication Date

2-16-2024

Publication Title

JACC Advances

Abstract

BACKGROUND: Low stroke volume index < 35 ml/m

OBJECTIVES: The purpose of this study was to analyze the risk associated with PLF in severe aortic stenosis for men and women randomized to TAVR or SAVR.

METHODS: Patients with ejection fraction ≥50% from the PARTNER (Placement of Aortic Transcatheter Valves) 2 and 3 trials were stratified by sex and treatment arm. The impact of PLF on the 2-year occurrence of the composite of death or heart failure hospitalization (primary endpoint) and of all-cause mortality alone (secondary endpoint) was analyzed. Analysis of variance was used to assess baseline differences between groups. Multivariate Cox regression analysis was used to identify predictors of the endpoint.

RESULTS: Out of 2,242 patients, PLF was present in 390 men and 239 women (30% vs 26%,

CONCLUSIONS: In women with PLF, TAVR may improve outcomes compared to SAVR. PLF appears to have less impact on outcomes in men.

Volume

3

Issue

3

First Page

100853

DOI

10.1016/j.jacadv.2024.100853

ISSN

2772-963X

PubMed ID

38938841

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