Cardiovascular Disease and COVID-19 Vaccines: A Systematic Review and Analysis of Published Cases.

Authors

Abdulrhman Khaity
Ala' Abdala Mohamad Rababah
Omar A. Abdelwahab
Khaled Albakri
Rehab Adel Diab
Nada Mostafa Al-Dardery
Mahmoud Abbassy
Balqees M. Al-Hanaqtah
Ahmed K. Awad
Tamam Mohamad, Beaumont Health

Document Type

Article

Publication Date

9-13-2023

Publication Title

European Cardiology

Abstract

As vaccination against COVID-19 became more widespread, side-effects that were not initially detected during clinical trials became more prominent. The aim of this systematic review is to discuss reports of adverse cardiovascular events associated with COVID-19 vaccination. Databases were searched from inception up to August 2022 to identify case reports and case series reporting on patients with cardiovascular disease after COVID-19 vaccination. This study assessed 150 published cases. Of these, 109 were case reports and 41 were case series. The majority of patients were male (n=302, 86.6%), with a mean age of 27.6 ± 16.7 years. Of the included patients, 268 (76.6%) had myocarditis, 50 (14.6%) had myopericarditis, 8 (2.3%) had pericarditis, and only 4 (1.1%) had stress-induced cardiomyopathy. Moreover, 30 (8.6%) and 11 (3.1%) were diagnosed with arrhythmia and ischaemic heart disease, respectively. Ultimately, cardiovascular complications after COVID-19 vaccination include myocarditis, myopericarditis, ischaemic heart disease and arrhythmia. The young population, especially young male patients, could be more vulnerable to myocarditis.

Volume

18

First Page

e54

Recommended Citation

Khaity A, Rababah AAM, Abdelwahab OA, Albakri K, Diab RA, Al-Dardery NM, et al. [Mohamad T]. Cardiovascular disease and COVID-19 vaccines: a systematic review and analysis of published cases. Eur Cardiol. 2023 Sep 13;18:e54. doi: 10.15420/ecr.2023.01. PMID: 37745168.

DOI

10.15420/ecr.2023.01

ISSN

1758-3764

PubMed ID

37745168