"How early can atherosclerosis be detected by coronary CT angiography? " by Rhanderson Cardoso, Andrew D Choi et al.
 

How early can atherosclerosis be detected by coronary CT angiography? Insights from quantitative CT analysis of serial scans in the PARADIGM trial.

Document Type

Article

Publication Date

10-3-2023

Publication Title

Journal of cardiovascular computed tomography

Abstract

BACKGROUND: Non-obstructing small coronary plaques may not be well recognized by expert readers during coronary computed tomography angiography (CCTA) evaluation. Recent developments in atherosclerosis imaging quantitative computed tomography (AI-QCT) enabled by machine learning allow for whole-heart coronary phenotyping of atherosclerosis, but its diagnostic role for detection of small plaques on CCTA is unknown.

METHODS: We performed AI-QCT in patients who underwent serial CCTA in the multinational PARADIGM study. AI-QCT results were verified by a level III experienced reader, who was blinded to baseline and follow-up status of CCTA. This retrospective analysis aimed to characterize small plaques on baseline CCTA and evaluate their serial changes on follow-up imaging. Small plaques were defined as a total plaque volume <50 >mm

RESULTS: A total of 99 patients with 502 small plaques were included. The median total plaque volume was 6.8 mm

CONCLUSION: In this retrospective analysis from the PARADIGM study, small plaques (<50 >mm

Volume

S1934-5925

Issue

23

First Page

00426-4

DOI

10.1016/j.jcct.2023.08.012

ISSN

1876-861X

PubMed ID

37798157

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