Influence of Obesity on Coronary Artery Disease and Clinical Outcomes in the ADVANCE Registry.
Circ Cardiovasc Imaging
BACKGROUND: The relationship between body size and cardiovascular events is complex. This study utilized the ADVANCE (Assessing Diagnostic Value of Noninvasive FFR
METHODS: The ADVANCE registry enrolled patients undergoing evaluation for clinically suspected CAD who had >30% stenosis on cardiac computed tomography angiography. Patients were stratified by BMI: normal/m
RESULTS: Among 5014 patients, 2166 (43.2%) had a normal BMI, 1883 (37.6%) were overweight, and 965 (19.2%) were obese. Patients with obesity were younger and more likely to have comorbidities, including diabetes and hypertension (all
CONCLUSIONS: Patients with obesity in the ADVANCE registry were less likely to have anatomically obstructive CAD by cardiac computed tomography angiography but had a similar degree of physiologically significant CAD by FFR
Lowenstern A, Ng N, Takagi H, Rymer JA, Koweek LM, Douglas PS et al. [Chinnaiyan K,] Influence of obesity on coronary artery disease and clinical outcomes in the ADVANCE registry. Circ Cardiovasc Imaging. 2023 May;16(5):e014850. doi: 10.1161/CIRCIMAGING.122.014850. Epub 2023 May 16. PMID: 37192296.