Title

Differential progression of coronary atherosclerosis according to plaque composition: a cluster analysis of PARADIGM registry data.

Document Type

Article

Publication Date

8-24-2021

Publication Title

Scientific reports

Abstract

Patient-specific phenotyping of coronary atherosclerosis would facilitate personalized risk assessment and preventive treatment. We explored whether unsupervised cluster analysis can categorize patients with coronary atherosclerosis according to their plaque composition, and determined how these differing plaque composition profiles impact plaque progression. Patients with coronary atherosclerotic plaque (n = 947; median age, 62 years; 59% male) were enrolled from a prospective multi-national registry of consecutive patients who underwent serial coronary computed tomography angiography (median inter-scan duration, 3.3 years). K-means clustering applied to the percent volume of each plaque component and identified 4 clusters of patients with distinct plaque composition. Cluster 1 (n = 52), which comprised mainly fibro-fatty plaque with a significant necrotic core (median, 55.7% and 16.0% of the total plaque volume, respectively), showed the least total plaque volume (PV) progression (+ 23.3 mm

Volume

11

Issue

1

First Page

17121

DOI

10.1038/s41598-021-96616-w

ISSN

2045-2322

PubMed ID

34429500

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