Differential progression of coronary atherosclerosis according to plaque composition: a cluster analysis of PARADIGM registry data.
Document Type
Article
Publication Date
8-24-2021
Publication Title
Scientific reports
Abstract
Patient-specific phenotyping of coronary atherosclerosis would facilitate personalized risk assessment and preventive treatment. We explored whether unsupervised cluster analysis can categorize patients with coronary atherosclerosis according to their plaque composition, and determined how these differing plaque composition profiles impact plaque progression. Patients with coronary atherosclerotic plaque (n = 947; median age, 62 years; 59% male) were enrolled from a prospective multi-national registry of consecutive patients who underwent serial coronary computed tomography angiography (median inter-scan duration, 3.3 years). K-means clustering applied to the percent volume of each plaque component and identified 4 clusters of patients with distinct plaque composition. Cluster 1 (n = 52), which comprised mainly fibro-fatty plaque with a significant necrotic core (median, 55.7% and 16.0% of the total plaque volume, respectively), showed the least total plaque volume (PV) progression (+ 23.3 mm
Volume
11
Issue
1
First Page
17121
Recommended Citation
Yoon YE, Baskaran L, Lee BC, Pandey MK, Goebel B, Lee SE, Sung JM, Andreini D, Al-Mallah MH, Budoff MJ, Cademartiri F, Chinnaiyan K, Choi JH, Chun EJ, Conte E, Gottlieb I, Hadamitzky M, Kim YJ, Lee BK, Leipsic JA, Maffei E, Marques H, de Araújo Gonçalves P, Pontone G, Shin S, Narula J, Bax JJ, Lin FY, Shaw L, Chang HJ. Differential progression of coronary atherosclerosis according to plaque composition: a cluster analysis of PARADIGM registry data. Sci Rep. 2021 Aug 24;11(1):17121. doi: 10.1038/s41598-021-96616-w. PMID: 34429500; PMCID: PMC8385056.
DOI
10.1038/s41598-021-96616-w
ISSN
2045-2322
PubMed ID
34429500