Association between metabolic syndrome and euthyroid nodular goiter: a case-control study.

Document Type

Article

Publication Date

12-30-2019

Publication Title

Colomb Med (Cali)

Abstract

Background: Metabolic syndrome is a cluster of metabolic abnormalities and abdominal obesity; its pathophysiologic basis, insulin resistance, has been shown to act as agent in thyroid cell proliferation. Few studies analyze the relationship between metabolic syndrome and thyroid nodular disease, with a substantial knowledge gap.

Objective: Determine the association between metabolic syndrome and nodular thyroid disease in a region with adequate iodine intake.

Methods: Case-control study. A total of 182 patients referred to radiology to undergo thyroid ultrasonography due to suspicion of thyroid disease. Cases had at least one thyroid nodule greater than 3 mm (n= 91). Controls did not have evidence of thyroid nodules (n= 91).

Results: Bivariate analysis showed a significant association between metabolic syndrome and the presence of thyroid nodule (OR 2.56, 95% CI: 1.41-4.66,

Conclusion: The thyroid nodular disease is associated with increased risk of metabolic syndrome, specifically decreased HDL and impaired fasting glucose levels were the factors that increased association was found.

Volume

50

Issue

4

First Page

239

Last Page

251

DOI

10.25100/cm.v50i4.2833

ISSN

1657-9534

PubMed ID

32476690

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