Postoperative Lisinopril-Induced Laryngeal Angioedema: Inflammatory Mediators and Medical Therapies

Document Type

Conference Proceeding

Publication Date



A 62 y.o. female with PMH of hyperthyroidism, morbid obesity, T2DM, HTN, and HLD presented for total thyroidectomy due to Graves disease. Although she has been on lisinopril for 2 years, she developed postoperative angioedema suspected to be from restarting lisinopril and progressed to severe unilateral tongue swelling. The patient was taken to the OR for awake fiberoptic intubation and remained on a ventilator for 2 days until the swelling subsided. We will discuss the symptomatology and pathophysiology of histamine versus bradykinin-induced angioedema and the medical and procedural perioperative therapies for management of this airway emergency.


American Society of Anesthesiologists Annual Meeting, October 12-16, 2023, San Francisco, CA