Recurrent Hyperhemolysis Syndrome in Sickle Cell Disease.

Authors

Rafey Rehman, Oakland University William Beaumont School of Medicine Medical Student
Saad B. Saadat, Oakland University William Beaumont School of Medicine Medical Student
Deanna H. Tran, Oakland University William Beaumont School of Medicine Medical Student
Sinziana Constantinescu, Beaumont Health Resident
Yusuf Qamruzzaman, Beaumont Health

Document Type

Article

Publication Date

5-12-2021

Publication Title

Cureus

Abstract

Sickle cell disease is a disorder of hemoglobin. The abnormal hemoglobin S disrupts blood flow, thereby resulting in acute painful sickle cell crisis. These episodes frequently prompt packed red blood cell transfusions to replace a patient's functional hemoglobin stores. Production of alloantibodies and autoantibodies to these transfusions can result in a rare, but serious, complication known as hyperhemolysis syndrome. Hyperhemolysis syndrome presents several challenges in regard to its acute management and the consequent difficulties in finding future compatible blood products. We report a case of recurrent hyperhemolysis syndrome. Both episodes occurred following orthopedic procedures, and the recurrent episode proved refractory to multiple treatments.

Volume

13

Issue

5

First Page

e14991

Recommended Citation

Rehman R, Saadat SB, Tran DH, Constantinescu S, Qamruzzaman Y. Recurrent Hyperhemolysis Syndrome in Sickle Cell Disease. Cureus. 2021 May 12;13(5):e14991. doi: 10.7759/cureus.14991. PMID: 34131536; PMCID: PMC8195550.

DOI

10.7759/cureus.14991

ISSN

2168-8184

PubMed ID

34131536