Native vs Prosthetic Valve Histoplasma capsulatum Infective Endocarditis: A Case Report and Systemic Literature Review Comparing Patient Presentation, Treatment Modalities, Clinical Outcomes, and Diagnostic Laboratory Testing

Authors

Bobby L Boyanton
Harry Boamah
Carl B. Lauter, Beaumont Health

Document Type

Article

Publication Date

7-14-2021

Publication Title

Open forum infectious diseases

Abstract

Histoplasma capsulatum is a rare cause of fungal endocarditis that affects both native and prosthetic valves. It is associated with a high mortality rate if not diagnosed early and treated with a combination of antifungal therapy and surgical intervention. We present a case of a 47-year-old man with histoplasmosis infective endocarditis. He was successfully treated with antifungal therapy and surgical replacement of the infected bioprosthetic aortic valve. Our systemic literature review includes 52 articles encompassing 60 individual cases of H. capsulatum infective endocarditis from 1940 to 2020. Patient presentations, diagnostic laboratory testing accuracy, treatment modalities, and patient outcomes comparing and contrasting native and prosthetic valve infection are described.

Volume

8

Issue

8

First Page

ofab360

Recommended Citation

Boyanton BL Jr, Boamah H, Lauter CB. Native vs Prosthetic Valve Histoplasma capsulatum Infective Endocarditis: A Case Report and Systemic Literature Review Comparing Patient Presentation, Treatment Modalities, Clinical Outcomes, and Diagnostic Laboratory Testing. Open Forum Infect Dis. 2021 Jul 14;8(8):ofab360. doi: 10.1093/ofid/ofab360. PMID: 34381842; PMCID: PMC8351801.

DOI

10.1093/ofid/ofab360

ISSN

2328-8957

PubMed ID

34381842