The Incidence of New or Worsening OAB Symptoms in Patients With Prior SARS COV-2 Infection
Journal of Urology
INTRODUCTION AND OBJECTIVE:
Investigators from our institution were the first US group to identify de novo genitourinary symptoms, such as frequency, urgency, nocturia, and pain/pressure, in individuals with prior COVID-19 infection. They termed this condition COVID-19 associated cystitis (CAC). Our study aims to establish the incidence of worsening or de-novo CAC, and to determine the correlation of CAC with serology status and antibody levels.
After IRB approval, 19,128 individuals from the largest COVID-19 serology study (BLAST COVID Study Group) were invited to participate in a follow-up study, with 1,895 subsequent respondents. Participants were retrospectively asked to score their OAB symptoms at three different time points: prior to the pandemic, 2 months after COVID-19 infection (if applicable), and at the present time. Genitourinary symptoms were assessed using the ICIQ-OAB.
Of the 1,895 participants, 81.7% (n=1,548) were female, 16.5% male (n=312), 1.9% other/unknown (n=35). Most were Caucasian (85.8%), followed by African American (4.1%), Asian (3.8%), and Hispanic (1.4%). A third of participants (n=605) were COVID-19 positive as defined by positive serology or PCR test. Of these, 492 had 2 months post infection data with 36.4% (n=179/492) reporting an increase of ≥1 unit on the ICIQ-OAB compared to pre-pandemic. Out of these, 22% (n=40/179) were de novo. Comparing pre-pandemic to present symptoms, 35.7% (n=219) of participants with prior COVID-19 infection had an increase of ≥1 unit on the ICIQ-OAB, compared to 15.7% (n=202) of uninfected patients (OR: 2.99, 99.6Cl, 2.21, 4.05, p (r=-0.10)and were weakly correlated in those with a positive serology test (r= 0.14).
In this study, we demonstrate that patients infected with COVID-19 are at increased risk for developing new or worsening OAB symptoms. No correlation was found between antibody levels and OAB symptoms in patients with prior COVID-19 infection. Participants are being followed prospectively to assess the progression of OAB symptoms in patients with CAC.
Roberts LH, Zwaans B, Chancellor M, Peters K, Padmanabhan P. The incidence of new or worsening OAB symptoms in patients with prior SARS COV-2 infection. J Urol. 2022 May;207(Suppl 5):e363-e364. doi:10.1097/JU.0000000000002559.08.
American Urological Association Annual Meeting, May 13-16, 2022, New Orleans, LA.
International Continence Society Annual Meeting, September 7-10, 2022, Vienna, Austria.
Robert LH, Zwaans B, Chancellor M, Peters K, Padmanabhan P. The incidence of new or worsening OAB symptoms in patients with prior SARS COV-2 infection. Continence. 2022 Jun;2(Suppl 2):100364. doi:10.1016/j.cont.2022.100364.