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Relationship Between Obesity and Triple-Negative Breast Cancer: A Retrospective Study
Mariam Aoun, Anna Jahshan, Nayana Dekhne, and Varna Taranikanti
Publication Date: 5-2-2022
INTRODUCTION
Several research studies have identified a positive correlation between obesity and specific receptor statuses in breast cancer, including ER-positive, PR-positive, and HER2-positive breast cancers. However, triple-negative breast cancer (TNBC) in particular has not been studied in relation to body mass index (BMI), which suggests that an analysis of triple-negative breast cancer and its relation to obesity is warranted. This study aims to analyze the association between triple-negative breast cancer and BMI through a retrospective analysis in order to further guide patient counseling about TNBC risk factors. -
Multiple Endocrine Neoplasia Type 1 in a Young Man With Seizures
Nitya Batra, Nishant Aggarwal, Shailesh Niroula, Daniel Misra, Peter Czako, and Daniel Shelden
Publication Date: 10-2022
Introduction
Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder involving mutation of the MEN1 gene. Clinically it is defined by tumors of the pituitary, parathyroid, and the entero-pancreatic endocrine cells. Other tumors have been associated with MEN1. We present a case of a previously healthy young man presenting with seizures.
Discussion
We present a classic case of MEN1 in a patient with significant family history with the presence of primary hyperparathyroidism, pituitary microadenoma, and duodenopancreatic NETs. • Interestingly, rare presentation of MEN1 as refractory seizures have been reported secondary to hyperinsulinemic hypoglycemia, but our patient was euglycemic with appropriate levels of insulin and C-peptide. This suggests an alternative etiology that is not well documented in available literature. • Given the complex and highly specialized skills needed to diagnose and treat MEN1, involvement of a multidisciplinary team is vital.
Conclusion When the clinical suspicion for MEN1 is high, endocrinology evaluation with appropriate laboratory workup and targeted imaging of the typical endocrine organs as described for this patient are advised with careful multidisciplinary management and follow-up.
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Incidental Pathogenic Fibrin-Associated Diffuse Large B-Cell Lymphoma Found During Aorto-Biiliac Bypass
Peter Habib, Thomas Serena, Caitlin Flynn, Aaron Hartkop, Elizabeth Wey, David Lang, and Eugene Laveroni Jr
Publication Date: 5-2022
Introduction • Fibrin-associated diffuse large B-cell lymphoma (FA-DLBCL) is an extremely rare form of Epstein-Barr virus positive (EBV+) non-Hodgkin’s lymphoma. • This case presents a rare and unique presentation of a pathological non-Hodgkin’s lymphoma
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Relationship Between Smoking and Triple-Negative Breast Cancer: A Retrospective Analysis
Anna Jahshan, Mariam Aoun, Nayana Dekhne, and Varna Taranikanti
Publication Date: 5-2-2022
INTRODUCTION
Breast cancer is currently the most common cancer by incidence among women in the United States with high mortality. Compared to other specific types, triple-negative breast cancer (TNBC) is considered to be an aggressive cancer with poor prognosis. Hence, it is important to study the risk factors associated with it. Smoking has been implicated in many cancers, including breast cancer. However, there is no evidence in literature that has shown a relationship between smoking and a specific type of breast cancer. The goal of this study is to analyze the relationship between smoking and TNBC so that we may improve the understanding of the risk factors related to this type of breast cancer. -
Clearance of the Cervical Spine in Obtunded Pediatric Blunt Trauma Patients: Quality Assessment of an Existing Clearance Pathway
Rachel Kalthoff, Elizabeth Boudiab, Diane Studzinski, Nathan Novotny, Pavan Brahmamdam, and Begum Akay
Publication Date: 5-2-2022
INTRODUCTION
Obtunded patients following blunt trauma need clearance of the cervical spine (c-spine) that cannot depend on a clinical exam. Our center’s current pediatric c-spine evaluation pathway includes both Computed Tomography (CT) and Magnetic Resonance Imaging (MRI). The objective of this study was to review our use of both CT and MRI for obtunded pediatric trauma patients to assess the quality of our pathway and utility of MRI. -
Factors Influencing Reintubation in Self Extubated Pediatric Intensive Care Unit Patients
Ahmed Naseem, Ameer Al-Hadidi, Morta Lapkus, Patrick Karabon, Begum Akay, and Paras Khandar
Publication Date: 5-2-2022
NTRODUCTION
Intubated pediatric patients that self-extubate may be particularly susceptible to reintubation. Identifying factors that increase risk of reintubation allows for better monitoring and response in cases of self-extubation and can potentially identify patients needing reintubation. -
Radioactive iodine therapy (RAIT) in N1 papillary thyroid cancer: Are we overtreating?
Elizabeth Odil, Jordan Reilly, Fionna Sun, Diane Studzinski, Rose E. Callahan, and Sapna Nagar
Publication Date: 4-28-2022
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A Rare Case of Subcutaneous Panniculitis-Like T-cell Lymphoma
Blake Seelbinder, Angela Kim, Marcos Rosado, Mohamed Musheinesh, Amanda Cimino, John Pui, Armen Korkigian, and Craig Gordon
Publication Date: 5-2022
Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare and typically slow growing variant of T-cell lymphoma. The clinical course usually mimics infectious panniculitis. It characteristically affects the subcutaneous adipose tissue of the trunk or extremities without resultant lymph node involvement. It comprises
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Association of Gut Metabolomic Biomarkers with Sleeve Gastrectomy Weight-Loss Outcomes
Pamela Spicer, Wendy Miller, Kathryn Ziegler, and Stewart Graham
Publication Date: 5-2-2022
INTRODUCTION
Obesity is a prevalent health challenge with high morbidity and many associated chronic diseases. Sleeve gastrectomy is currently the predominant intervention for obesity. However, weight loss results are variable. The mechanisms and factors influencing this variability are not well understood. We evaluated the correlation of metabolomic biomarkers with weight-loss.
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