Mutational landscape of radiation-induced angiosarcoma in breast cancer patients

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Purpose/Objective(s): Angiosarcomas are rare but aggressive tumors of endothelial origin representing approximately 1% of all soft tissue sarcomas. Radiation-induced angiosarcomas (RAAs) are a recognized complication of radiation therapy, and approximately 40% of all RAAs occur after adjuvant radiotherapy for breast cancer. The incidence of breast RAA has increased over the years due to the more common use of adjuvant radiotherapy as part of breast-conserving treatment. Radiation-induced breast angiosarcomas have poor prognosis, and relatively little is known about what cellular pathways are involved. In this study, we use targeted next generation DNA sequencing (NGS) to determine whether there is a specific radiation-induced mutation signature and to determine the key genes and pathways altered in breast RAA


59th Annual Meeting of the American Society for Radiation Oncology (ASTRO), San Diego, CA, September 24-27, 2017.