Metabolomic Profiling of Cerebral Palsy Brain Tissue Reveals Novel Central Biomarkers and Biochemical Pathways Associated with the Disease: A Pilot Study.

Authors

Zeynep Alpay Savasan, Beaumont Health
Ali Yilmaz, Beaumont Health
Zafer Ugur, Beaumont Health
Buket Aydas, Beaumont Health
Ray O Bahado-Singh, Beaumont Health
Stewart F. Graham, Beaumont Health

Document Type

Article

Publication Date

2-2-2019

Abstract

Cerebral palsy (CP) is one of the most common causes of motor disability in childhood, with complex and heterogeneous etiopathophysiology and clinical presentation. Understanding the metabolic processes associated with the disease may aid in the discovery of preventive measures and therapy. Tissue samples (caudate nucleus) were obtained from post-mortem CP cases (

Volume

9

Issue

2

Recommended Citation

Bahado-Singh RO, Yilmaz A, Bisgin H, Turkoglu O, Kumar P, Sherman E, Mrazik A, Odibo A, Graham SF. Artificial intelligence and the analysis of multi-platform metabolomics data for the detection of intrauterine growth restriction. PLoS One. 2019;14(4):e0214121. doi: 10.1371/journal.pone.0214121. eCollection 2019. PubMed PMID: 30998683; PubMed Central PMCID: PMC6472728.

ISSN

2218-1989

PubMed ID

30717353