Acute outcomes for the full US cohort of the FLASH mechanical thrombectomy registry in pulmonary embolism.

Document Type

Article

Publication Date

2-20-2023

Publication Title

EuroIntervention

Abstract

BACKGROUND: Evidence supporting interventional pulmonary embolism (PE) treatment is needed.

AIMS: We aimed to evaluate the acute safety and effectiveness of mechanical thrombectomy for intermediate- and high-risk PE in a large real-world population.

METHODS: FLASH is a multicentre, prospective registry enrolling up to 1,000 US and European PE patients treated with mechanical thrombectomy using the FlowTriever System. The primary safety endpoint is a major adverse event composite including device-related death and major bleeding at 48 hours, and intraprocedural adverse events. Acute mortality and 48-hour outcomes are reported. Multivariate regression analysed characteristics associated with pulmonary artery pressure and dyspnoea improvement.

RESULTS: Among 800 patients in the full US cohort, 76.7% had intermediate-high risk PE, 7.9% had high-risk PE, and 32.1% had thrombolytic contraindications. Major adverse events occurred in 1.8% of patients. All-cause mortality was 0.3% at 48-hour follow-up and 0.8% at 30-day follow-up, with no device-related deaths. Immediate haemodynamic improvements included a 7.6 mmHg mean drop in mean pulmonary artery pressure (-23.0%; p

Volume

18

Issue

14

First Page

1201

Last Page

1212

DOI

10.4244/EIJ-D-22-00732

ISSN

1969-6213

PubMed ID

36349702

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