Title

Tumor Voxel Dose-Response Matrix and Dose Prescription Function Derived Using

Document Type

Article

Publication Date

5-1-2019

Publication Title

International journal of radiation oncology, biology, physics

Abstract

PURPOSE: To construct a tumor voxel dose response matrix (DRM) and dose prescription function (DPF) for adaptive dose painting by number (DPbN) based on treatment feedback of fluoro-2-deoxyglucose (FGD) positron emission tomography (PET)/computed tomography (CT) imaging.

METHODS AND MATERIALS: FDG-PET/CT images obtained before and after chemoradiation therapy and at weekly chemoradiation therapy sessions for each of 18 patients with head and neck cancer, as well as the treatment outcomes, were used in the modeling. All weekly and posttreatment PET/CT images were registered voxel-to-voxel to the corresponding pretreatment baseline PET/CT image. Tumor voxel DRM was created using serial FDG-PET imaging of each patient with respect to the baseline standardized uptake value (SUV

RESULTS: Large intertumoral and intratumoral variations on both tumor voxels (SUV

CONCLUSIONS: Tumor voxel (SUV

Volume

104

Issue

1

First Page

207

Last Page

218

DOI

10.1016/j.ijrobp.2019.01.077

ISSN

1879-355X

PubMed ID

30684661

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