Tumor Voxel Dose-Response Matrix and Dose Prescription Function Derived Using
International journal of radiation oncology, biology, physics
PURPOSE: To construct a tumor voxel dose response matrix (DRM) and dose prescription function (DPF) for adaptive dose painting by number (DPbN) based on treatment feedback of fluoro-2-deoxyglucose (FGD) positron emission tomography (PET)/computed tomography (CT) imaging.
METHODS AND MATERIALS: FDG-PET/CT images obtained before and after chemoradiation therapy and at weekly chemoradiation therapy sessions for each of 18 patients with head and neck cancer, as well as the treatment outcomes, were used in the modeling. All weekly and posttreatment PET/CT images were registered voxel-to-voxel to the corresponding pretreatment baseline PET/CT image. Tumor voxel DRM was created using serial FDG-PET imaging of each patient with respect to the baseline standardized uptake value (SUV
RESULTS: Large intertumoral and intratumoral variations on both tumor voxels (SUV
CONCLUSIONS: Tumor voxel (SUV
Yan D, Chen S, Krauss DJ, Chen PY, Chinnaiyan P, Wilson GD. Tumor Voxel Dose-Response Matrix and Dose Prescription Function Derived Using 18F-FDG PET/CT Images for Adaptive Dose Painting by Number. Int J Radiat Oncol Biol Phys. 2019 May 1;104(1):207-218. doi: 10.1016/j.ijrobp.2019.01.077. Epub 2019 Jan 24. PMID: 30684661.