Title

Low Dose Brain Irradiation Reduces Amyloid-β and Tau in 3xTg-AD Mice

Document Type

Article

Publication Date

1-1-2020

Publication Title

Journal of Alzheimer's disease : JAD

Abstract

We have previously reported that low doses of external beam ionizing irradiation reduced amyloid-β (Aβ) plaques and improved cognition in APP/PS1 mice. In this study we investigated the effects of radiation in an age-matched series of 3xTg-AD mice. Mice were hemibrain-irradiated with 5 fractions of 2 Gy and sacrificed 8 weeks after the end of treatment. Aβ and tau were assessed using immunohistochemistry and quantified using image analysis with Definiens Tissue Studio. We observed a significant reduction in Aβ plaque burden and tau staining; these two parameters were significantly correlated. This preliminary data is further support that low doses of radiation may be beneficial in Alzheimer's disease.

Volume

75

Issue

1

First Page

15

Last Page

21

DOI

10.3233/JAD-200030

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