Low Dose Brain Irradiation Reduces Amyloid-β and Tau in 3xTg-AD Mice
Journal of Alzheimer's disease : JAD
We have previously reported that low doses of external beam ionizing irradiation reduced amyloid-β (Aβ) plaques and improved cognition in APP/PS1 mice. In this study we investigated the effects of radiation in an age-matched series of 3xTg-AD mice. Mice were hemibrain-irradiated with 5 fractions of 2 Gy and sacrificed 8 weeks after the end of treatment. Aβ and tau were assessed using immunohistochemistry and quantified using image analysis with Definiens Tissue Studio. We observed a significant reduction in Aβ plaque burden and tau staining; these two parameters were significantly correlated. This preliminary data is further support that low doses of radiation may be beneficial in Alzheimer's disease.
Wilson, George D.; Wilson, Thomas G.; Hanna, Alaa; Fontanesi, Giovanni; Kulchycki, Justin; Buelow, Katie; Pruetz, Barbara L.; Michael, Daniel B.; Chinnaiyan, Prakash; Maddens, Michael E.; Martinez, Alvaro A.; and Fontanesi, James, "Low Dose Brain Irradiation Reduces Amyloid-β and Tau in 3xTg-AD Mice" (2020). Articles. 45.