Title
The Rationale for Radiation Therapy in Alzheimer's Disease.
Document Type
Article
Publication Date
3-7-2023
Publication Title
Radiation research
Abstract
Alzheimer's Disease (AD) represents a major health problem without effective treatments. As the incidence of the disease will continue to rise, it is imperative to find new treatment options to halt or slow disease progression. In recent years, several groups have begun to study the utility of low total dose radiation therapy (LTDRT) to inhibit some of the pathological features of AD and improve cognition in a variety of animal models. These preclinical studies have led to Phase 1 and 2 trials in different centers around the world. In this review, we present and interpret the pre-clinical evidence report some preliminary clinical data from a Phase 2 trial in early-stage AD patients.
Volume
Online ahead of print.
Recommended Citation
Wilson GD, Rogers CL, Mehta MP, Marples B, Michael DB, Welsh JS, et al. [Fontanesi J] The rationale for radiation therapy in Alzheimer's disease. Radiat Res. 2023 Mar 7. doi: 10.1667/RADE-22-00179.1. Epub ahead of print. PMID: 36881804.
DOI
10.1667/RADE-22-00179.1
ISSN
1938-5404
PubMed ID
36881804