Improving dosimetric outcome for hippocampus and cochlea sparing whole brain radiotherapy using spot-scanning proton arc therapy

Xuanfeng Ding, Beaumont Health
Jun Zhou, Beaumont Health
Xiaoqiang Li, Beaumont Health
Kevin Blas, Beaumont Health
Gang Liu, Beaumont Health
Yinan Wang, Beaumont Health
An Qin, Beaumont Health
Prakash Chinnaiyan, Beaumont Health
Di Yan, Beaumont Health
Craig Stevens, Beaumont Health
Inga Grills, Beaumont Health
Peyman Kabolizadeh, Beaumont Health


© 2019, © 2019 Acta Oncologica Foundation. Summary: This feasibility study shows that Spot-scanning Proton Arc therapy (SPArc) is able to significantly reduce the dose to the hippocampus and cochlea compared to both Volumetric Modulated Arc Photon Therapy (VMAT) and the robust optimized Intensity Modulated Proton Therapy (ro-IMPT) plans in whole brain radiotherapy. Furthermore, SPArc not only improves plan robustness but could potentially deliver a treatment as efficient as ro-IMPT when proton system’s energy layer switch time is less than 1 s.