Rectal cancer in young patients: incidence and outcome disparities.
Journal of Gastrointestinal Oncology
Background: There is an alarming rise in incidence among young patients with rectal cancer. The National Cancer Database (NCDB) and Surveillance, Epidemiology, and End Results Analysis (SEER) databases may help identify population level disparities in incidence and cancer-related outcomes.
Methods: A total of 197,178 patients within the SEER 18 registry and 221,886 patients from the NCDB database with rectal cancer were evaluated in this retrospective cohort study. The analyzed cohort consisted of young (
Results: A total of 6,144 young patients were identified from the SEER 18 registry and a total of 17,819 young patients were identified from the NCDB. From 1990 to 2016, there was a significant change in rectal cancer incidence, with a steadily increasing APC of 3.06 (P
Conclusions: The current study adds to the growing body of literature demonstrating an alarming increase in incidence of rectal cancer among young patients. Moreover, the incidence appears to be increasing particularly among young white patients and driven by stage III disease.
Quinn TJ, Kabolizadeh P. Rectal cancer in young patients: incidence and outcome disparities. J Gastrointest Oncol. 2020 Oct;11(5):880-893. doi: 10.21037/jgo-20-197. PMID: 33209484; PMCID: PMC7657826.